"Those who have not imbibed the prejudices of philosophers, are easily convinced that natural knowledge is to be founded on experiment and observation." (Colin Maclaurin, "An Account of Sir Isaac Newton’s Philosophical Discoveries", 1748)
"We have three principal means: observation of nature, reflection, and experiment. Observation gathers the facts reflection combines them, experiment verifies the result of the combination. It is essential that the observation of nature be assiduous, that reflection be profound, and that experimentation be exact. Rarely does one see these abilities in combination. And so, creative geniuses are not common." (Denis Diderot, "On the Interpretation of Nature", 1753)
"Facts, observations, experiments - these are the materials of a great edifice, but in assembling them we must combine them into classes, distinguish which belongs to which order and to which part of the whole each pertains." (Antoine L Lavoisier, "Mémoires de l’Académie Royale des Sciences", 1777)
"The art of drawing conclusions from experiments and observations consists in evaluating probabilities and in estimating whether they are sufficiently great or numerous enough to constitute proofs. This kind of calculation is more complicated and more difficult than it is commonly thought to be […]" (Antoine-Laurent Lavoisier, cca. 1790)
"We must trust to nothing but facts: These are presented to us by Nature, and cannot deceive. We ought, in every instance, to submit our reasoning to the test of experiment, and never to search for truth but by the natural road of experiment and observation." (Antoin-Laurent de Lavoisiere, "Elements of Chemistry", 1790)
"Conjecture may lead you to form opinions, but it cannot produce knowledge. Natural philosophy must be built upon the phenomena of nature discovered by observation and experiment." (George Adams, "Lectures on Natural and Experimental Philosophy" Vol. 1, 1794)
"[Precision] is the very soul of science; and its attainment afford the only criterion, or at least the best, of the truth of theories, and the correctness of experiments." (John F W Herschel, "A Preliminary Discourse on the Study of Natural Philosophy", 1830)
"The hypothesis, by suggesting observations and experiments, puts us upon the road to that independent evidence if it be really attainable; and till it be attained, the hypothesis ought not to count for more than a suspicion." (John S Mill, "A System of Logic, Ratiocinative and Inductive", 1843)
"The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention." (William Whewell, "Philosophy of the Inductive Sciences" Vol. 2, 1847)
"An anticipative idea or an hypothesis is, then, the necessary starting point for all experimental reasoning. Without it, we could not make any investigation at all nor learn anything; we could only pile up sterile observations. If we experiment without a preconceived idea, we should move at random […]" (Claude Bernard, "An Introduction to the Study of Experimental Medicine", 1865)
"Isolated facts and experiments have in themselves no value, however great their number may be. They only become valuable in a theoretical or practical point of view when they make us acquainted with the law of a series of uniformly recurring phenomena, or, it may be, only give a negative result showing an incompleteness in our knowledge of such a law, till then held to be perfect." (Hermann von Helmholtz, "The Aim and Progress of Physical Science", 1869)
"It is surprising to learn the number of causes of error which enter into the simplest experiment, when we strive to attain rigid accuracy." (William S Jevons, "The Principles of Science: A Treatise on Logic and Scientific Method", 1874)
"A discoverer is a tester of scientific ideas; he must not only be able to imagine likely hypotheses, and to select suitable ones for investigation, but, as hypotheses may be true or untrue, he must also be competent to invent appropriate experiments for testing them, and to devise the requisite apparatus and arrangements." (George Gore, "The Art of Scientific Discovery", 1878)
"Even one well-made observation will be enough in many cases, just as one well-constructed experiment often suffices for the establishment of a law." (Émile Durkheim, "The Rules of Sociological Method", "The Rules of Sociological Method", 1895)
"Every experiment, every observation has, besides its immediate result, effects which, in proportion to its value, spread always on all sides into ever distant parts of knowledge." (Sir Michael Foster, "Annual Report of the Board of Regents of the Smithsonian Institution", 1898)
"If the number of experiments be very large, we may have precise information as to the value of the mean, but if our sample be small, we have two sources of uncertainty: (I) owing to the 'error of random sampling' the mean of our series of experiments deviates more or less widely from the mean of the population, and (2) the sample is not sufficiently large to determine what is the law of distribution of individuals." William S Gosset, "The Probable Error of a Mean", Biometrika, 1908)
"An experiment is an observation that can be repeated, isolated and varied. The more frequently you can repeat an observation, the more likely are you to see clearly what is there and to describe accurately what you have seen. The more strictly you can isolate an observation, the easier does your task of observation become, and the less danger is there of your being led astray by irrelevant circumstances, or of placing emphasis on the wrong point. The more widely you can vary an observation, the more clearly will be the uniformity of experience stand out, and the better is your chance of discovering laws." (Edward B Titchener, "A Text-Book of Psychology", 1909)
"Theory is the best guide for experiment - that were it not for theory and the problems and hypotheses that come out of it, we would not know the points we wanted to verify, and hence would experiment aimlessly" (Henry Hazlitt, "Thinking as a Science", 1916)
"A scientist, whether theorist or experimenter, puts forward statements, or systems of statements, and tests them step by step. In the field of the empirical sciences, more particularly, he constructs hypotheses, or systems of theories, and tests them against experience by observation and experiment." (Karl Popper, "The Logic of Scientific Discovery", 1934)
"While it is true that theory often sets difficult, if not impossible tasks for the experiment, it does, on the other hand, often lighten the work of the experimenter by disclosing cogent relationships which make possible the indirect determination of inaccessible quantities and thus render difficult measurements unnecessary." (Georg Joos, "Theoretical Physics", 1934)
"In relation to any experiment we may speak of this hypothesis as the null hypothesis, and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis." (Ronald Fisher, "The Design of Experiments", 1935)
"Statistics is a scientific discipline concerned with collection, analysis, and interpretation of data obtained from observation or experiment. The subject has a coherent structure based on the theory of Probability and includes many different procedures which contribute to research and development throughout the whole of Science and Technology." (Egon Pearson, 1936)
"Experiment as compared with mere observation has some of the characteristics of cross-examining nature rather than merely overhearing her." (Alan Gregg, "The Furtherance of Medical Research", 1941)
"The well-known virtue of the experimental method is that it brings situational variables under tight control. It thus permits rigorous tests of hypotheses and confidential statements about causation. The correlational method, for its part, can study what man has not learned to control. Nature has been experimenting since the beginning of time, with a boldness and complexity far beyond the resources of science. The correlator’s mission is to observe and organize the data of nature’s experiments." (Lee J Cronbach, "The Two Disciplines of Scientific Psychology", The American Psychologist Vol. 12, 1957)
"A satisfactory prediction of the sequential properties of learning data from a single experiment is by no means a final test of a model. Numerous other criteria - and some more demanding - can be specified. For example, a model with specific numerical parameter values should be invariant to changes in independent variables that explicitly enter in the model." (Robert R Bush & Frederick Mosteller,"A Comparison of Eight Models?", Studies in Mathematical Learning Theory, 1959)
"Mathematical statistics provides an exceptionally clear example of the relationship between mathematics and the external world. The external world provides the experimentally measured distribution curve; mathematics provides the equation (the mathematical model) that corresponds to the empirical curve. The statistician may be guided by a thought experiment in finding the corresponding equation." (Marshall J Walker, "The Nature of Scientific Thought", 1963)
"Observation, reason, and experiment make up what we call the scientific method. (Richard Feynman, "Mainly mechanics, radiation, and heat", 1963)
"Science consists simply of the formulation and testing of hypotheses based on observational evidence; experiments are important where applicable, but their function is merely to simplify observation by imposing controlled conditions." (Henry L Batten, "Evolution of the Earth", 1971)
"In moving from conjecture to experimental data, (D), experiments must be designed which make best use of the experimenter's current state of knowledge and which best illuminate his conjecture. In moving from data to modified conjecture, (A), data must be analyzed so as to accurately present information in a manner which is readily understood by the experimenter."
"Statistical methods are tools of scientific investigation. Scientific investigation is a controlled learning process in which various aspects of a problem are illuminated as the study proceeds. It can be thought of as a major iteration within which secondary iterations occur. The major iteration is that in which a tentative conjecture suggests an experiment, appropriate analysis of the data so generated leads to a modified conjecture, and this in turn leads to a new experiment, and so on." (George E P Box & George C Tjao, "Bayesian Inference in Statistical Analysis", 1973)
"A hypothesis is empirical or scientific only if it can be tested by experience. […] A hypothesis or theory which cannot be, at least in principle, falsified by empirical observations and experiments does not belong to the realm of science." (Francisco J Ayala, "Biological Evolution: Natural Selection or Random Walk", American Scientist, 1974)
"An experiment is a failure only when it also fails adequately to test the hypothesis in question, when the data it produces don't prove anything one way or the other." (Robert M Pirsig, "Zen and the Art of Motorcycle Maintenance", 1974)
"The point is that every experiment involves an error, the magnitude of which is not known beforehand and it varies from one experiment to another. For this reason, no matter what finite number of experiments have been carried out, the arithmetic mean of the values obtained will contain an error. Of course, if the experiments are conducted under identical conditions and the errors are random errors, then the error of the mean will diminish as the number of experiments is increased, but it cannot be reduced to zero for a finite number of experiments. […] The choice of entities for an experiment must be perfectly random, so that even an apparently inessential cause could not lead to erroneous conclusions."
"The essential function of a hypothesis consists in the guidance it affords to new observations and experiments, by which our conjecture is either confirmed or refuted." (Ernst Mach, "Knowledge and Error: Sketches on the Psychology of Enquiry", 1976)
"Theoretical scientists, inching away from the safe and known, skirting the point of no return, confront nature with a free invention of the intellect. They strip the discovery down and wire it into place in the form of mathematical models or other abstractions that define the perceived relation exactly. The now-naked idea is scrutinized with as much coldness and outward lack of pity as the naturally warm human heart can muster. They try to put it to use, devising experiments or field observations to test its claims. By the rules of scientific procedure it is then either discarded or temporarily sustained. Either way, the central theory encompassing it grows. If the abstractions survive they generate new knowledge from which further exploratory trips of the mind can be planned. Through the repeated alternation between flights of the imagination and the accretion of hard data, a mutual agreement on the workings of the world is written, in the form of natural law." (Edward O Wilson, "Biophilia", 1984)
"The only touchstone for empirical truth is experiment and observation." (Heinz Pagels, "Perfect Symmetry: The Search for the Beginning of Time", 1985)
"Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory." (Stephen Hawking, "A Brief History of Time", 1988)
"Scientists use mathematics to build mental universes. They write down mathematical descriptions - models - that capture essential fragments of how they think the world behaves. Then they analyse their consequences. This is called 'theory'. They test their theories against observations: this is called 'experiment'. Depending on the result, they may modify the mathematical model and repeat the cycle until theory and experiment agree. Not that it's really that simple; but that's the general gist of it, the essence of the scientific method." (Ian Stewart & Martin Golubitsky, "Fearful Symmetry: Is God a Geometer?", 1992)
"Clearly, science is not simply a matter of observing facts. Every scientific theory also expresses a worldview. Philosophical preconceptions determine where facts are sought, how experiments are designed, and which conclusions are drawn from them." (Nancy R Pearcey & Charles B. Thaxton, "The Soul of Science: Christian Faith and Natural Philosophy", 1994)
"Probability theory is an ideal tool for formalizing uncertainty in situations where class frequencies are known or where evidence is based on outcomes of a sufficiently long series of independent random experiments. Possibility theory, on the other hand, is ideal for formalizing incomplete information expressed in terms of fuzzy propositions." (George Klir, "Fuzzy sets and fuzzy logic", 1995)
"The methods of science include controlled experiments, classification, pattern recognition, analysis, and deduction. In the humanities we apply analogy, metaphor, criticism, and (e)valuation. In design we devise alternatives, form patterns, synthesize, use conjecture, and model solutions." (Béla H Bánáthy, "Designing Social Systems in a Changing World", 1996)
"[…] because observations are all we have, we take them seriously. We choose hard data and the framework of mathematics as our guides, not unrestrained imagination or unrelenting skepticism, and seek the simplest yet most wide-reaching theories capable of explaining and predicting the outcome of today’s and future experiments." (Brian Greene, "The Fabric of the Cosmos", 2004)
"In science, for a theory to be believed, it must make a prediction - different from those made by previous theories - for an experiment not yet done. For the experiment to be meaningful, we must be able to get an answer that disagrees with that prediction. When this is the case, we say that a theory is falsifiable - vulnerable to being shown false. The theory also has to be confirmable, it must be possible to verify a new prediction that only this theory makes. Only when a theory has been tested and the results agree with the theory do we advance the statement to the rank of a true scientific theory." (Lee Smolin, "The Trouble with Physics", 2006)
"The ultimate arbiter of truth is experiment, not the comfort one derives from one's a priori beliefs, nor the beauty or elegance one ascribes to one's theoretical models." (Lawrence M Krauss, "A Universe from Nothing: Why There Is Something Rather than Nothing", 2012)
"Self-selection bias occurs when people choose to be in the data - for example, when people choose to go to college, marry, or have children. […] Self-selection bias is pervasive in 'observational data', where we collect data by observing what people do. Because these people chose to do what they are doing, their choices may reflect who they are. This self-selection bias could be avoided with a controlled experiment in which people are randomly assigned to groups and told what to do."
"We encounter regression in many contexts - pretty much whenever we see an imperfect measure of what we are trying to measure. Standardized tests are obviously an imperfect measure of ability. [...] Each experimental score is an imperfect measure of 'ability', the benefits from the layout. To the extent there is randomness in this experiment - and there surely is - the prospective benefits from the layout that has the highest score are probably closer to the mean than was the score." (Gary Smith, "Standard Deviations", 2014)
"Observation and experiment, without a rational hypothesis, is like a man groping at objects at random with his eyes shut." (Henry P Tappan, "Elements of Logic", 2015)
"The dialectical interplay of experiment and theory is a key driving force of modern science. Experimental data do only have meaning in the light of a particular model or at least a theoretical background. Reversely theoretical considerations may be logically consistent as well as intellectually elegant: Without experimental evidence they are a mere exercise of thought no matter how difficult they are. Data analysis is a connector between experiment and theory: Its techniques advise possibilities of model extraction as well as model testing with experimental data."
"If your experiment needs statistics, you ought to have done a better experiment." (Ernest Rutherford)
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